MSCI 930 - Molecular and Cellular Basis of Pathogenesis

Cr Hrs: 3 (48-0-0)
GR

The goal of this course is to explore the interactions between viruses and their hosts that result in pathogenic effects and disease. The course will provide an understanding of the molecular and cellular mechanisms responsible for pathogenesis resulting from infection of a human host by viruses, bacteria and fungi. Classes will build on information presented in IP805 ?Essentials of Molecular Biology? and in MSCI 931 ?Immune Response to Pathogens? using defined viral, bacterial and fungal model systems to provide a comprehensive and fundamental understanding of the concepts that govern host-pathogen interactions and that lead to disease. Upon completion of the course, students will gain a comprehensive understanding of the molecular and cellular bases for pathogenesis resulting from infection of a human host by viral, bacterial and fungal pathogens. Students will gain a comprehensive understanding of virulence factors, how their expression is controlled at both the molecular and cellular levels and how these pathogen-specific factors affect cells and tissues of the host. The topics are discussed using a format involving in-class discussion of key concepts and answers to pre-class study questions followed, by in-class discussion of pertinent assigned research papers. The papers to be read and discussed include classical papers establishing essential concepts and current papers that exemplify and add detail to the topic under discussion. Combined with the information learned in the prerequisite courses, students will also have a comprehensive understanding of host-pathogen relationships that ultimately lead to the elimination of infectious agents or the establishment of productive infections.

Grade Mode: Standard

Instructional Method: Lecture

Prerequisites: MSCI 931, IP 805
Term offered: Spring

Spring - Instructor of Record: Pat Ryan