Pharmaceutical Sciences, Medicinal Chemistry Concentration, PhD

Program Description

A PhD in Pharmaceutical Sciences is available with concentrations in medicinal chemistry; pharmaceutics; bioanalysis; and pharmacometrics. Medicinal chemistry research includes design, synthesis, and biological evaluation of new compounds with potential for use in the treatment of diseases like cancer and disorders of the endocrine, cardiovascular, central and peripheral nervous systems, and infectious diseases. Pharmaceutics research includes the design, development and evaluation of drug delivery systems, injectables, and biotechnology drugs and the study of the disposition and pharmacokinetics of drugs and metabolites in humans, animals, and cells. Bioanalysis research includes the development and application of state-of-the-art analytical technology to detect and quantify molecular entities of biological and pharmaceutical interest, such as drugs or biomarkers. Pharmacometrics research includes the quantitative assessment of drug disposition (pharmacokinetics) and effects (pharmacodynamics) using mathematical models based on biology, physiology, pharmacology and disease.

Admission and Selection

Applications for the PhD in Pharmaceutical Sciences are accepted from students with a Bachelor of Science (BS) or a Master of Science (MS) degree in pharmacy, chemistry, biology, mathematics, engineering, or other appropriate disciplines. The normal admission time for new students is in the Fall term, which begins mid-August. Prospective graduate students should submit a completed application form and supporting documents by March 15th for the Fall term. Applications are reviewed as received. The admission requirements are:

• A minimum grade point average of 3.0 on a 4.0 scale
• A minimum revised Graduate Record Examination (GRE) combined verbal and quantitative score of 300 and a 3.5 on the analytical section.
• Any applicant to the graduate program whose first language is not English and who has earned neither a bachelor’s nor a master’s degree from a college or university in an English-speaking country must have achieved a TOEFL score of at least 213/79 on the computer-based/Internet- based exam or an IELTS score of 6.5 (earned within 2 years prior to application). Any applicant whose first language is not English but who has earned a baccalaureate or advanced degree from a college or university in an English-speaking country where instruction was in English may be exempted from the requirement for the TOEFL or IELTS examination.
• Three letters of recommendation.
• Transcripts from any non-US institution must be verified and certified to generate a grade point average (GPA) based on a 4.0 scale. Verification must be completed before March 1.

Technical Standards and Accommodations

The minimum abilities for eligibility to participate successfully in educational programs and activities by students enrolled in the College of Graduate Health Sciences are listed below. All persons who wish to enter one of the programs in the College should be aware of the minimum abilities required for success. Admission decisions for the College programs do not take disabilities into consideration; students may disclose their disabilities after admission.

Minimum abilities are as follows:

1. To make proper assessments and ethical judgments regarding research and professional decisions.
2. To communicate effectively with colleagues and professional staff.
3. To acquire necessary information developed through classroom instruction, laboratory experience, independent learning, and consultation.
4. To search and evaluate articles in the scientific literature.
5. To obtain, interpret, and accurately document research data.
6. To complete computer-based assignments and use computers.
7. To understand and carry out safety rules and precautions in the laboratory.
8. To handle emergencies in the laboratory, including fire, exposure to dangerous agents, and explosions.

These abilities may be accomplished through direct student response, use of prosthetic devices, or personal assistance (e.g., readers, signers, and note takers). Upon admission, students are invited to disclose any disabilities (with certification) to the Student Academic Support Services and Inclusion (SASSI) https://www.uthsc.edu/sassi/. The college will provide reasonable accommodations, as required by the student’s documented disabilities with SASSI, and at the student’s written request to the Dean, College of Graduate Health Sciences. Purchase of prosthetic devices to aid the student in meeting these requirements is the responsibility of the student. On a case-by-case basis and upon written request of the student, the College may assist in providing attending services.

Curriculum Summary and (Typical) Sequence

Medicinal Chemistry

In addition to required and elective didactic coursework, completion of a doctoral dissertation describing a research investigation is required.

Promotion and Graduation

Students must maintain a 3.0 grade point average or greater throughout the program.

Non-Completion of Degree

A student who has satisfactorily completed a minimum of 30 credit hours may choose not to finish the additional coursework and research required for a PhD and instead choose to graduate with an Master of Science degree in Pharmaceutical Sciences  . This option requires approval by the mentor, faculty committee, and track director. Notification of the College with a request for admission to MS degree candidacy must occur no later than the second month of the term in which the student intends to graduate. Completion of the MS degree requires full-time registration and both an oral and written analysis of the work completed.

Admission to Candidacy

The student must apply for PhD degree candidacy no later than two terms prior to the term in which the dissertation is presented. A comprehensive examination (oral and written) covering the fields indicated by the program must be passed prior to admission to candidacy. In the event of failure, the candidate may not appear for reexamination until permission is granted by the program. The result of the second examination is final.

Admission to candidacy for this degree depends upon the student’s (1) passing the required comprehensive examination, (2) demonstration of research potential and accomplishment at least equivalent to that for completion of a master’s thesis, (3) certification by the student’s Faculty Committee and the Program Chair, and (4) approval by the Dean. Upon admission to candidacy, all graduate students, including those who have been enrolled part-time, must be enrolled full-time for the remainder of their program, unless an exception is approved by the Dean.

Research, Electronic Dissertation, and Oral Defense

Research accomplishment is a principal requirement for the degree of Doctor of Philosophy, and the dissertation must show substantial evidence of independently achieved and original results. This research and preparation of the dissertation must in each case be conducted in accordance with general College policies and under the immediate direction of the student’s Research Advisor and Faculty Committee. The dissertation is written after completion of experiments or other graduate studies designed to answer the questions posed by the statement of the problem. The scientific content and style of the dissertation are the responsibility of the student and student’s Faculty Committee. The dissertation must be formatted and delivered according to the electronic thesis and dissertation policies outlined in these bylaws under “ET/D Program Policies”.

Additional information regarding this program is available at http://grad.uthsc.edu/Programs/index.php?page=Programs.