MSCI 812 - Physical Biochemistry and Applications in Structural Biology

Cr Hrs: 3 (48-0-0)
A Lecture in physical biochemistry that is divided into two parts. The first part covers the major experimental techniques used in physical biochemistry, including X-ray crystallography, NMR spectroscopy, general spectroscopy, and thermodynamics. The theoretical and experimental bases of the techniques will be emphasized. The second part addresses the structure and mechanisms of biological macromolecules, and many of the major classes of proteins will be discussed, as well as the structures of DNA and RNA. Emphasis will be on the physicochemical processes that control the folding and stability of macromolecules and on the processes that determine their unique structures and functions. The course will be accompanied by problem sets and practical sessions in the laboratory, and students will also be provided with software for viewing and manipulating structures on personal computers.

Grade Mode: Standard
Instructional Method: Lecture
Prerequisites: permission of instructor

Term offered: Spring (Not currently offered)

Spring - Instructor of Record: Stephen W White